- About Our Integrative Medical Clinic
- Director's Greeting
- Vice Director
- Doctors, Dentists & Staff
- Clinic Introduction
- Consultation Hours
- Access
About Our Integrative Medical Clinic
Our clinic, located in Sannomiya, Kobe, offers comprehensive care through internal medicine, gastroenterology, psychosomatic medicine, dentistry, and orthodontics under one roof.
Comprehensive Care Through Medical–Dental Collaboration
With the concept of “Healing the whole body through the gut and mouth,” our medical and dental teams work closely together. Our gastroenterology specialists examine the entire digestive tract—from the oral cavity to the anus—providing holistic care aimed at achieving fundamental health improvement.
Specialized Treatment Approaches
- Fecal Microbiota Transplantation (FMT)
- Treatment for Irritable Bowel Syndrome (IBS) and Small Intestinal Bacterial Overgrowth (SIBO)
- Orthomolecular (Nutritional) Therapy
- Preventive Dental Program
By combining optimization of the intestinal environment with professional oral care, we help maximize the body’s natural healing power. Our clinic also provides holistic medical care led by board-certified cancer specialists.
Integrating modern medicine with complementary therapies, we offer personalized treatment plans tailored to each patient’s unique needs.
Director's Greeting
At Shirotani Bio Wellness Clinic, we practice integrative medicine that views the body, mind, and environment as one connected system, with a focus on the gut and oral health. Having experienced the limitations of symptomatic treatment in conventional medicine, we aim to draw out the body’s natural healing power through approaches that emphasize coexistence with microorganisms, nutrition, and lifestyle habits. It is our sincere hope to help each individual regain true health through personalized care.
Our clinic provides careful, holistic support for conditions such as “mibyo” (pre-disease state) and unexplained chronic malaise through intestinal microbiota transplantation (FMT), molecular nutrition therapy, preventive dentistry, and orthodontic care. We value harmony among mind, body, and environment, and strive to help patients restore their innate vitality and brightness. In today’s society, more people suffer from conditions without visible abnormalities. That is why we place importance on identifying the “root causes” that do not appear in test results — by listening attentively and examining carefully. Please feel free to consult us with confidence.
Director Masahiko Shirotani
Career
| 1995 | Graduated from the Faculty of Medicine, Tokyo Medical and Dental University (now Tokyo Science University). Joined the 4th Department of Internal Medicine, Kobe University (Prof. Tsutomu Chiba). Resident in Internal Medicine, Kobe University Hospital. |
|---|---|
| 1996 | Resident in Internal Medicine, Miki Municipal Hospital. Transferred to the Department of Gastroenterology, Kyoto University (Prof. Chiba’s appointment as Chair). |
| 1998 | Medical staff, Department of Pathology, Kyoto University Hospital. Deeply impressed by Dr. Hayao Kawai’s lecture on “Creative Illness” at a university seminar for young physicians. |
| 1999 | Gastroenterologist, Hyogo Prefectural Tsukaguchi Hospital (now Amagasaki General Medical Center). |
| 2000 | Diagnosed with ulcerative colitis. This experience reaffirmed the importance of integrative medical approaches beyond conventional Western medicine. |
| 2002 | Underwent endoscopy training under Prof. Hiromi Shinya at Shinya Clinic and Beth Israel Hospital, New York. Studied “intestinal complexion (Choso)” as proposed by Dr. Shinya. |
| 2005 | Appointed Vice Director, Shirotani Clinic Medical Corporation. |
| 2007 | Encountered Dr. Carl Simonton and began studying Simonton Therapy and psycho-oncology. |
| 2007 | Experienced acute exacerbation of ulcerative colitis. As medical treatment was ineffective, underwent total colectomy, which strengthened his resolve to pursue integrative medicine. |
| 2008 | Part-time physician (hospice), Department of General Internal Medicine, Kobe Adventist Hospital. Participated in the group therapy facilitator training course for cancer patients under Dr. Takashi Hosaka (current Chief, Psycho-Oncology Dept., St. Luke’s International Hospital). Began “Group Therapy for Cancer Patients” in 2009. |
| 2009 | Completed Simonton Therapy training at Simonton Cancer Center (California). Appointed Director and Chairman, Shirotani Clinic Medical Corporation. |
| 2014 | Board Member, Kanzaki Medical Association (–2016). |
| 2016 | Opened Lukes Ashiya Clinic. |
| 2025 | Opened Shirotani Bio Wellness Clinic. |
Qualifications
Certified Member, Japanese Society of Internal Medicine
Board-Certified Specialist, Japanese Society of Gastroenterology
Board-Certified Specialist, Japan Gastroenterological Endoscopy Society
Certified Occupational Physician, Japan Medical Association
Executive Director, Clinical Research Association for Intestinal Flora Transplantation
Certified Counselor, Simonton Therapy
Director, NPO Simonton Therapy Association
Certified Physician, Cell Environment Design Medicine, Kyorin Preventive Medicine Research Institute
Certified Physician, Clinical Molecular Nutrition Medicine Research Association
Certified Staff, Elizabeth Kübler-Ross Workshop (formerly LDT Workshop)
Memberships
Japanese Society of Internal Medicine
Japanese Society of Gastroenterology
Japan Gastroenterological Endoscopy Society
Japanese Society for Integrative Medicine
Japan Society of Anti-Aging Medicine
Clinical Molecular Nutrition Medicine Research Association
Clinical Hydrogen Therapy Research Association
Japanese Society for Focal Infection Research
Clinical Research Association for Intestinal Flora Transplantation
Japan Society for Preventive Clinical Medicine
Member, International Plant-Based Nutrition Healthcare Conference
Publication
Living in Harmony with Your Gut Microbiota
Written by a doctor who underwent total colectomy — the amazing power of the gut and its microbiota!
Ulcerative colitis, cancer, atopic dermatitis, depression, autism, chronic fatigue…
From diet and lifestyle tips to the groundbreaking treatment “Fecal Microbiota Transplantation (FMT),” this book explains how to overcome physical and mental disorders.
Table of Contents
Chapter 1: The Gut — Commander of Life
- If your gut isn’t happy, you won’t feel happy either
Your gut and your emotions are inseparably connected
“Happy hormones” are produced by gut bacteria, not just in the brain!
Why “the gut is the second brain” is true
You are almost not “you” — the incredible influence of microorganisms
Gut bacteria are tireless workers
True health means “nurturing your gut bacteria well”
Even arteriosclerosis is related to gut bacteria
Your anxiety may come not from your brain, but from your gut
Stress damages both brain and gut
Good, bad, and opportunistic bacteria are actually teammates, not enemies
Where our immune cells—the guardians of health—reside
How traditional Japanese stamina amazed foreigners — what’s behind it?
Chapter 2: Your Gut Is in Danger
Imbalance in gut microbiota is linked to all diseases
Gut environment is largely determined between birth and age three
Gut bacteria sharpen your intuition
Excessive cleanliness may lead to allergies
Substances that disrupt our gut environment
The vital role of short-chain fatty acids
Overgrowth of Candida in the gut can cause serious problems
“New-type malnutrition” despite sufficient food intake
Zinc deficiency damages intestinal cells
Minerals are key players in the body’s energy production
Overuse of medication carries hidden risks
Too much gluten and casein worsens gut health
Excess sugar damages the intestinal lining
To protect your gut, eat more omega-3 fatty acids
Leaky gut syndrome triggers various diseases
What is SIBO — the small intestinal bacterial overgrowth gaining attention?
Various tests to assess your gut environment
Chapter 3: Why Balancing the Gut Is So Important
Chronic inflammation as the root of many diseases
Leaky gut as a cause of systemic inflammation
Convenience foods as a hidden cause of illness
Bone broth’s powerful gut-healing properties
Moderate exercise to maintain gut health
The connection between mental and gut balance
People who taught me the importance of “heart” in medicine
Letting go of fixed beliefs and taking the first step
Balancing the mind to unleash natural healing power
Happy mind, happy cells
Three essential elements to regain health
Integrating mind and gut through the “Gut–Brain Program”
Chapter 4: What I Realized and Became Certain Of After Total Colectomy
Living with irritable bowel syndrome since childhood
The invisible suffering of IBS
Reaching the limits of medical treatment and undergoing total colectomy
How learning Simonton Therapy transformed my medical perspective
How encountering FMT accelerated my inner transformation
Chapter 5: The Reality and Effects of Fecal Microbiota Transplantation
How your stool can help treat disease
The long history of fecal microbiota transplantation
Next-generation FMT and its unique bacterial solution
Deputy Director Introduction
To help our patients live a life full of genuine smiles and a higher quality of health — that is our mission.
Through orthodontic treatment, we hope to support you in achieving that goal. Improving dental alignment not only enhances appearance but also positively affects chewing ability, breathing, posture, and even mental well-being. The long treatment period provides valuable time to reflect and care for yourself. During this journey, we hope you will discover your true charm and potential. We are committed to creating a comfortable and welcoming environment where you can receive treatment with peace of mind.
Deputy Director Tadashi Shirotani
Career
| 1998 | Graduated from Tokyo Medical and Dental University (now Tokyo University of Science), Faculty of Dentistry |
|---|---|
| 2002 | Completed Doctoral Course in Orthodontics, Graduate School of Dentistry, Hiroshima University |
| 2002 | Worked at Hiroshima University Hospital, Faculty of Dentistry |
| 2003 | Worked at a specialized orthodontic clinic Certified Orthodontist, The Japanese Orthodontic Society (No. 2471) |
| 2004 | Opened a specialized orthodontic clinic outside the prefecture Served as Director for over 20 years |
To the present
Memberships
Japanese Orthodontic Society (JOS)
Certified Nonprofit Organization – Japan Focal Infection Research Association
Japanese Society for Jaw Deformities
Japanese Society for Temporomandibular Joint
Japanese Cleft Palate Association
Japanese Society of Anti-Aging Medicine
Clinical Hydrogen Therapy Research Association
Chugoku-Shikoku Orthodontic Society
Intravenous Therapy Research Association
Doctors, Dentists, and Staff Introduction
Internal Medicine / Oncology Physician
Yoshishige Okuno
Career
| 1963 | Born in Osaka City |
|---|---|
| 1988 | Graduated from Kyoto University, Faculty of Medicine / Doctor of Medicine |
Specializes in radiation therapy, cancer treatment, and palliative care.
After graduation, joined the Department of Radiology, Kyoto University.
Served as a board-certified radiation oncologist and core member of the palliative care team at university hospitals and regional cancer centers.
During this time, participated in numerous clinical trials and treated a wide variety of cancer patients through radiation therapy and palliative care.
Based on extensive experience in Western medical oncology, he founded Okuno Clinic in September 2010 in front of JR Rokkomichi Station, Kobe, with the goal of improving cancer patients’ quality of life (QOL).
Currently provides holistic medicine that treats the mind, body, and spirit, based on Western medicine.
Qualifications / Memberships
Board-Certified Radiation Oncologist, Japan Radiological Society
Certified Cancer Treatment Physician, Japanese Board of Cancer Therapy
Completed Palliative Care Leadership Training Program
Certified Spiritual Care Worker, Japan Spiritual Care Worker Association (NPO)
Completed Clinical Meditation Instructor Training Course
Certified NES Health Practitioner
Dentistry
Mayumi Yamamoto
Career
| 1998 | Graduated from Tokyo Medical and Dental University (now Tokyo University of Science), Faculty of Dentistry |
|---|---|
| 1998 | Joined Department of Prosthodontics, Hiroshima University Hospital |
| 2002 | Completed Doctoral Course in Prosthodontics, Graduate School of Dentistry, Hiroshima University |
| 2002 | Worked at Hiroshima University Hospital, Faculty of Dentistry |
| Subsequently worked at several dental clinics Currently in practice |
Dentistry
Chise Nobuhisa
Career
| 1998 | Graduated from Okayama University, Faculty of Dentistry |
|---|---|
| 1998 | Joined Department of Orthodontics, Hiroshima University Hospital |
| 2002 | Completed Doctoral Course in Orthodontics, Graduate School of Dentistry, Hiroshima University |
| 2003 | Certified Orthodontist, The Japanese Orthodontic Society (No. 2438) |
| Has since been contracted with multiple dental clinics and engaged in orthodontic treatment, currently in practice |
Affiliations
The Japanese Orthodontic Society
Nurses
T.S.
K.O.
N.U.
Dental Hygienists
M.S.
A.M.
Dental Technician
K.M.
Reception / Administration
S.T.
Y.T.
K.M.
Clinic Introduction
Exterior
Entrance
Reception
Consultation Room
Examination Room
Treatment Room
Treatment Room ②
Counseling Room
Consultation Hours
| Consultation Hours | Mon | Tue | Wed | Thu | Fri | Sat | Sun |
|---|---|---|---|---|---|---|---|
| 9:30–12:30 | – | ● | ● | ● | ● | ▲ | ■ |
| 14:00–18:00 | – | ● | ● | ● | ● | ▲ | – |
▲ Saturday… Morning: 9:30–12:30 / Afternoon: 14:00–17:00
■ 2nd & 4th Sundays… Morning: 9:30–12:30
Closed: Mondays (in principle), 1st, 3rd, and 5th Sundays, and public holidays
Appointments are prioritized at our clinic.
Access
〒650-0021
7F Wacore Kobe Sannomiya Building, 1-4-9 Sannomiya-cho, Chuo-ku, Kobe-shi, Hyogo
Clinic Entrance
When facing the first-floor restaurant “Bistro Ueshima,” please turn left into the narrow passageway on the right side of the restaurant — the building entrance is located there.
Map (Simplified)
This is a simplified map of our clinic.
If you have trouble finding the entrance, please feel free to contact us.
By Train
5-minute walk from Hanshin Main Line Sannomiya Station
7-minute walk from Hankyu Kobe Main Line Sannomiya Station
7-minute walk from JR Tokaido Main Line Sannomiya Station
By Car
The nearest parking lot is the Sannomiya Chuo-dori Municipal Parking (no discounts available).